Publicaties

 

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Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1
A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome
Hematopoietic stem cell transplantation for CTLA4 deficiency
The 10 warning signs: a time for a change?
Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells
The EUROclass trial: defining subgroups in common variable immunodeficiency
The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
International Consensus Document (ICON): Common Variable Immunodeficiency Disorders
Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity.
Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency
Leukocyte adhesion deficiencies.
A novel splice variant of FcγRIIa: a risk factor for anaphylaxis in patients with hypogammaglobulinemia
Identification of B cell defects using age-defined reference ranges for in vivo and in vitro B cell differentiation.
Cutaneous manifestations of primary immunodeficiency.
Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis.
Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies
Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects.
Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages.
Of mice and men: The factor H protein family and complement regulation.
Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years
Common variable immunodeficiency and hemophagocytic features associated with a FAS gene mutation
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.
Primary immunodeficiencies in the Netherlands: national patient data demonstrate the increased risk of malignancy
Singleton-Merten syndrome: an autosomal dominant disorder with variable expression
Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes
Overview of 15-year severe combined immunodeficiency in the Netherlands: towards newborn blood spot screening
On the dark side of therapies with immunoglobulin concentrates: the adverse events
Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe
Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations
Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?
Rhizopus oryzae skin infection treated with posaconazole in a boy with chronic granulomatous disease
Primary immunodeficiencies in the Netherlands: national patient data demonstrate the increased risk of malignancy
CD20 deficiency in humans results in impaired T cell-independent antibody responses
The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants
Incidence of invasive group B streptococcal disease and pathogen genotype distribution in newborn babies in the Netherlands over 25 years: a nationwide surveillance study.
Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D
Educational paper: Defects in number and function of neutrophilic granulocytes causing primary immunodeficiency
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation.
Cytotoxic human CD4(+) T cells.
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection
A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells.
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
Incidence of invasive group B streptococcal disease and pathogen genotype distribution in newborn babies in the Netherlands over 25 years: a nationwide surveillance study